胰腺癌预后相关因素的分析研究

目的研究胰腺癌临床相关因素与预后的关系.方法：回顾性分析115例胰腺癌患者相关临床资料,进行是否影响预后的单因素方差分析,符合条件的纳入Cox比例风险模型进行多因素分析.结果：胰腺癌患者的预后与性别、糖尿病史、胰腺炎病史、肿瘤家族史、肿瘤部位、CA19-9异常无明显相关（P〉 0.05）;而与初诊原因、肿瘤大小、临床分期、胰周侵犯、远处转移、治疗方法、CEA是否异常有关（P〈 0.05）.其中初诊原因、肿瘤分期、胰周侵犯、远处转移、治疗方法与预后关系最密切（P〈 0.01）.结论：早期发现、根治性手术是改善胰腺癌预后最关键因素,TNM临床分期是判断预后的最可靠依据,血清CEA可评价胰腺癌疾病进展程度.

Analysis of Clinical Characteristics and Prognosis of Pancreatic Carcinoma

Objective To study the relationship between clinical pathological factors and prognosis of pan-creatic carcinoma. Methods Complete clinical material of 115 patients with pancreatic carcinoma was en？rolled in this retrospective study for purpose of prognosis analysis. All the factors were studied by statisticalmethod of univariate and multivariate（Cox＇S model） analysis. Results The prognosis of patients with pancreat-ic carcinoma was not significantly correlated with the sex, history of diabetes and of pancreatitis, family historyof carcinoma, tumor location and the level of CA19-9 （P 〉 0.05）; While the first symptoms, tumorsize, clinical stages, peripancreatic invasion, distant metastasis, treatment methods and the level of CEA were significantly correlated with prognosis（P 〈 0.05）;among them the first symptoms, tumor stages, pancreatic invasion, distant metastasis and treatment methods werethe most closely related （P 〈 0.01）. Conclusion Early detection and radical surgery are the most critical fac-tors in improving the prognosis of pancreatic carcinoma, TNM clinical stage is the most important factor to judgethe prognosis of pancreatic carcinoma. The level of serum CEA can be used to evaluate pancreatic carcinomaprogression.