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| NDV/MC联合治疗小鼠H_(22)腹水瘤的实验研究 | |
| 引用本文： | 尹致良,刘晓波,田伏洲,李小军,彭涛. NDV/MC联合治疗小鼠H_(22)腹水瘤的实验研究[J]. 西南国防医药, 1998, 0(1) |
| 作者姓名： | 尹致良 刘晓波 田伏洲 李小军 彭涛 |
| 作者单位： | 成都军区总医院普外实验室，成都军区总医院普外实验室，成都军区总医院普外实验室，成都军区总医院普外实验室，成都军区总医院普外实验室 成都 610083，成都 610083，成都 610083，成都 610083，成都 610083 |
| 摘 要： | 目的:探讨NDV/MC联合治疗小鼠H_(22)腹水瘤的协同增效作用,以提高对肿瘤的治疗效果。方法:将H_(22)瘤细胞接种小鼠腹腔后分成Hanks液、NDV、MC、NDV与MC组,每组给8只;分别用Hanks液、NDV、MC、NSV与MC联合治疗。结果:Hanks液组平均存活14.8d,存活率0.0％;NDV组存活19.6d,存活率12.5％;MC组存活18.8d,存活率25.0％;NDV与MC联合治疗组存活24.4d,存活率37.5％。结论:NDV与MC联合治疗小鼠H_(22)腹水瘤,疗效显著高于单纯NDV与单纯MC组,抗肿瘤效果有显著差异。 |
| 关 键 词： | 新城疫病毒(NDV) H_(22)腹水瘤 丝裂毒素C(MC) |
STUDY OF TREATMENT OF MOUSE BEARING H_(22) HEPATOCARCINOMA WITH NDV/MC |
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| Yin Zhiliang,Liu Xiaobo,Tian Fuzhou,et al,General Surgical Center of PLA,General Hospital of Chengdu Military Command,Chengdu,.. STUDY OF TREATMENT OF MOUSE BEARING H_(22) HEPATOCARCINOMA WITH NDV/MC[J]. Medical Journal of National Defending forces in Southwest China, 1998, 0(1) | |
| Authors: | Yin Zhiliang Liu Xiaobo Tian Fuzhou et al General Surgical Center of PLA General Hospital of Chengdu Military Command Chengdu . |
| Affiliation: | Yin Zhiliang,Liu Xiaobo,Tian Fuzhou,et al,General Surgical Center of PLA,General Hospital of Chengdu Military Command,Chengdu,610083. |
| Abstract: | Objective: To investigate the synergic effect of the new castle disease virus (NDV) and mitomycin C(MC) in treatment of mouse bearing H22 hepatocarinoma cells. Method: After intraperi-toneal injection with bearing H22 cells, the mice were divided into four groups, i. e. Hanks group, NDV group, MC group and NDV/MC group. There were eight mice in each group. They were treated with Hanks, NDV, MC and NDV/MC, respectivly. Results: The mean survial time(MST) was 14. 8 days and survival rate(SR) was 0% in Hanks group; MST=19. 6 days and SR = 12. 5% in NDV group ; MST=18. 8 days and SR = 25. 0% in MC group; MST = 24. 4 days and SR = 37. 5% in NDV/MC group; Conclusion: Treatment of mouse bearing H22 hepatocarcinoma with NDV/MC is more effective than with only NDV or MC. |
| Keywords: | new catle disease virus H22 hepatic carcinoma mitomycin C |
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