Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease |
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| Authors: | Hyeran Kim Young-Ah Kwon Inn Sook Ahn Sangha Kim Seonwoo Kim Sangmee Ahn Jo Doh Kwan Kim |
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| Affiliation: | 1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.;2Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Republic of Korea.;3Biostatistics Unit, Samsung Biomedical Research Institute, Seoul, Republic of Korea.;4Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Republic of Korea. |
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| Abstract: | ![]()
ObjectiveBiological markers for Alzheimer''s disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than the onset of clinical manifestations in AD.MethodsWe examined the lymphocyte expression of cell cycle proteins in AD patients, dementia controls (DC), and normal controls (NC). One-hundred seventeen subjects (36 AD, 31 DC, and 50 NC) were recruited. The cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were measured in peripheral lymphocytes. Cell cycle protein expression in the three groups was compared after adjusting for age and sex.ResultsThe levels of cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were significantly higher in AD patients than in the NC subjects. The DC group manifested intermediate levels of cell cycle proteins compared with the AD patients and the NC subjects. The present study indicates that cell cycle proteins are upregulated in the peripheral lymphocytes of AD patients.ConclusionCell cycle dysregulation in peripheral lymphocytes may present a promising starting point for identifying peripheral biomarkers of AD. |
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| Keywords: | Biomarker Cell cycle proteins Alzheimer''s disease Cyclin Cyclin-dependent kinase Peripheral lymphocyte |
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