|
|||||
|
|
| 63Ni-NiCl2在大鼠体内的药代动力学及其组织残留 | |
| 引用本文： | 李湛,王颢,吴王锁. 63Ni-NiCl2在大鼠体内的药代动力学及其组织残留[J]. 药学学报, 2008, 43(2): 224-226 |
| 作者姓名： | 李湛 王颢 吴王锁 |
| 作者单位： | 1. 兰州大学核科学与技术学院,甘肃,兰州,730000 2. 兰州大学基础医学院,甘肃,兰州,730000 |
| 摘 要： | 镍是动物体必需的微量元素,参与核酸和蛋白质的代谢、激素的调节过程,具有刺激生血、促进红细胞再生的功能[1],与激素、蛋白质和脂类的代谢也密切相关.国内相关研究较少,尤其使用同位素标记法研究更少. |
| 关 键 词： | 63Ni-NiCl2 吸收 药物残留 |
| 文章编号： | 0513-4870（2008）02-0224-03 |
| 收稿时间： | 2007-08-12 |
| 修稿时间： | 2007-08-12 |
Pharmacokinetic parameter and residua of 63Ni-NiCl2 in rat |
|
| LI Zhan,WANG Hao,WU Wang-suo. Pharmacokinetic parameter and residua of 63Ni-NiCl2 in rat[J]. Acta pharmaceutica Sinica, 2008, 43(2): 224-226 | |
| Authors: | LI Zhan WANG Hao WU Wang-suo |
| Affiliation: | School of Nuclear Science and Technology, Lanzhou 730000, China. |
| Abstract: | Absorption distribution and excretion of 63Ni-NiCl2, administered orally to rats were studied by using liquid scintillation counting method. It was observed that the concentration-time curves in blood fitted the two compartment model of pharmacokinetics, Ka=6.18 h(-1), T(1/2)alpha =0.79 h, T(1/2)beta=40.68 h, CL =0.42 mL kg(-1) h(-1), Tmax =0.53 h, Cmax=24,987.75 min(-1) mL(-1), and Vd=0.016 L kg(-1). After rats were treated by 63Ni-NiCl2 for 15 days, in 22 tissues tested, the contents of 63Ni-NiCl2 in hair, hypothalamus, hypophysis, pancreas, small and large intestines were higher, and the residua of 63Ni-NiCl2 was not discovered in liver, kidney and heart. Radioactivity eliminated was 83.27% by urine and feces, 54.86% by urine, 28.41% by feces. |
| Keywords: | ~63 Ni-NiCl_2 absorption residual medicine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |