Apparent glucose utilization in Walker 256 metastatic brain tumors |
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| Authors: | Ronald G Blasberg Mami Shinohara William R. Shapiro Clifford S. Patlak Karen D. Pettigrew Joseph D. Fenstermacher |
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| Affiliation: | (1) Present address: Nuclear Medicine Department, CC, National Institute of Health, Building 10, Room IC401, 20205 Bethesda, MarylanD, USA;(2) Laboratory of Cerebral Metabolism, National Institute of Mental Health, 20205 NIH, Bethesda, MD, USA;(3) Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University, 10021 New York, NY, USA;(4) Theoretical Statistics and Mathematics Branch, National Institute of Mental Health, 20205 NIH, Bethesda, MD, USA;(5) Present address: Department of Neurological Surgery, Health Sciences Center, State University of New York at Stony Brook, T12-082 Stony Brook, NY 11794, USA |
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| Abstract: | ![]()
Regional rates of apparent glucose utilization (GU) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid injection of WL-256 tumor cells in rats were measured using14C-deoxyglucose and quantitative auroradiography. Apparent glucose utilization was uniform within individual small and medium size tumors without necrosis, varied considerably among different tumors within this group, and did not correlate with tumor size or location. High values of GU in medium and large-size tumors correlated with viable-appearing tissue in contrast to necrotic tissue and were always 1.3 to 3 times higher than that of adjacent and contralateral nontumorous brain. The apparent net extraction of glucose (En*) in viable tumor regions was estimated to be several fold higher than that in remote brain tissue; analysis of this data for medium and large tumors indicates that the calculated values of GU and En* overestimate the actual rates of utilization and net extraction of glucose. Local cerebral glucose utilization (LCGU) was higher than normal adjacent to small tumors and lower than normal adjacent to large tumors. The LCGU in many gray-matter structures remote from the intracerebral tumors was reduced and roughly proportional to the metastatic tumor burden. The comparatively high uptake of 2-deoxyglucose by viable tumor cells has diagnostic and localization value and suggests that appropriate glucose analogues could be developed to produce a tumor-selective inhibition of glycolysis and tumoricidal effect.An abstract of this work has been presented: M. Shinohara, R. Blasberg, C. Patlak, W. Shapiro: Metastatic brain tumors: local cerebral glucose utilization, Neurology 29: 545, 1979 |
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| Keywords: | glucose utilization Walker 256 tumors metastatic brain tumors deoxyglucose quantitative autoradiography |
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