| 血管内皮细胞生长因子在斑秃皮损中的表达 |
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| 引用本文： | 康瑞花,高顺强,赵保亭,李艳华.血管内皮细胞生长因子在斑秃皮损中的表达[J].临床皮肤科杂志,2002,31(7):415-416. |
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| 作者姓名： | 康瑞花 高顺强 赵保亭 李艳华 |
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| 作者单位： | 河北医科大学第四医院皮肤科,河北,石家庄,050011 |
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| 摘 要： | 血管内皮细胞生长因子（vasculaqr endothelial cell growth factor,VEGF)是一种特殊作用于血管内皮细胞的丝裂原，在体内能诱导血管形成。为探讨VEGF为斑秃的关系，应用免疫组化的方法检测了VEGF在30例斑秃皮损中的表达和分布，以16例正常人头皮为对照。结果表明斑秃皮损中VEGF的表达明显低于正常对照。提示VEGF的表达下调可能与斑秃的发病有关。
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| 关 键 词： | 血管内皮细胞生长因子 斑秃 免疫组化 皮损 血管形成 |
| 文章编号： | 1000-4963(2002)07-0415-02 |
| 修稿时间： | 2001年8月13日 |
Expression of vascular endothelial cell growth factor in lesion of alopecia areata |
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| KANG Rui hua,GAO Shun qiang,ZHAO Bao ting,LI Yan hua.Expression of vascular endothelial cell growth factor in lesion of alopecia areata[J].Journal of Clinical Dermatology,2002,31(7):415-416. |
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| Authors: | KANG Rui hua GAO Shun qiang ZHAO Bao ting LI Yan hua |
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| Abstract: | Vascular endothelial cell growth factor(VEGF)is a mitogen which acts specifically on vascular endothelial cell.It induces vascularization in vivo.To study the relationship between the VEGF and alopecia areata(AA),the skin lesions of 30 AA were observed with immunohistochemistry.Sixteen normal scalp specimens were taken as controls.The result showed that the expressions of VEGF in the AA groups were significantly lower than those in controls.It suggested that decreased VEGF expression may be associated with pathogenesis of AA. |
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| Keywords: | vascular endothelial cell growth factor alopecia areata immunohistochemistry |
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