肺部手术围手术期氨溴索剂量的选择研究

目的：探讨肺部手术围手术期氨溴索的合适剂量。方法：选择在深圳市第二人民医院实施肺部手术的295例患者作为研究对象．分为对照组和A、B、C、D治疗组，每组各59例。A、B、C、D组术后分别使用30、60、90、120mg盐酸氨溴索，对照组使用生理盐水100mL。比较各组术后排痰情况、并发症发生率及抗生素使用时间。结果：治疗组治愈率、好转率高于对照组（P〈0．05）；C、D组治愈率、好转率均高于A、B组（P〈0．05）。对照组并发症发生率高于治疗；A、B组并发症发生率高于C、D组（P〈0．05）。对照组抗生素使用时间长于治疗组（P〈0．05），A、B、C组抗生素使用时间长于D组（P〈0．05）。结论：氨溴索可有效防止肺部手术围手术期的呼吸系统并发症，其临床剂量使用应适当偏用高剂量，具体最适剂量仍待进一步探索。

Perioperative dosing schemes for ambroxol in patients scheduled for lung surgery

Objective：To investigate the appropriate perioperative dosing scheme for ambroxol in patients scheduled for lung surgery. Methods： We randomly allocated 295 patients who were scheduled for lung surgeries in Shenzhen Second People＇ s Hospital to be treated with 100 mL natural saline intravenous injection （ control group, n = 59 ） , 30 mg ambroxol thrice daily （ group A, n = 59 ） , 60 mg ambroxol thrice daily （ group B, n = 59） , 90 mg ambroxol thrice daily （group C, n = 59 ） and 120 mg ambroxol thrice daily （group D, n = 59 ） , respectively. We next compared the volume of sputum expectorated, the incidence of respiratory complications and the use of antibiotics. Results： Compared with control group, all treatment groups yielded a significantly higher rates of recovery and remission yet a lower incidence rate of complications （ all P 〈 0.05 ）. This held true for the comparisons between groups C and D, and between groups A and B （ both P 〈 0. 05 ）. The control group was associated with a prolonged period of antibiotic use （all P 〈 0.05）. Compared with groups A, B and C, a longer period of antibiotic use was noted in group D （ all P 〈 0.05 ）. Conclusions： Ambroxol effectively prevents from the incidence of perioperative respiratory complications. Despite that relatively high doses of ambroxol are recommended for clinical application, the optical doses merits further studies.