| 帕金森氏病患者红细胞膜流动性与过氧化脂质改变的初步研究 |
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| 引用本文： | 罗曙光. 帕金森氏病患者红细胞膜流动性与过氧化脂质改变的初步研究[J]. 广西医学, 1997, 0(5) |
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| 作者姓名： | 罗曙光 |
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| 作者单位： | 广西医科大学第一附属医院 |
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| 摘 要： | 以１，６－ｄｉｐｈｅｎｙｌ－１，３，５－ｈｅｘａｔｒｅｎｅ（ＤＰＨ）作为荧光探剂，应用荧光偏振技术研究帕金森氏病（ＰＤ）患者和正常对照组的红细胞膜微粘度，及ＴＢＡ比色法测定血浆过氧化脂质（ＬＰＯ），结果表明ＰＤ患者的红细胞膜微粘度及血浆ＬＰＯ明显高于正常对照组，两指标间呈正相关关系。提示：检测红细胞膜流动性变化，可了解ＰＤ患者全身细胞受损害情况。
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| 关 键 词： | 帕金森氏病 膜流动性 膜微粘度 过氧化脂质 |
Preliminary study on changes of the fluidity of the erythrocyte membrane and serum lipid peroxide in patients with Parkinson disease. |
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| Luo shuguang.No. Preliminary study on changes of the fluidity of the erythrocyte membrane and serum lipid peroxide in patients with Parkinson disease.[J]. Guangxi Medical Journal, 1997, 0(5) |
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| Authors: | Luo shuguang.No |
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| Affiliation: | Nanning 530027 |
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| Abstract: | With 1,6-diphenyl-1,3,5-hexatrene(DPH)serving as a fluoresent agent,erythrocyte membrane microviscosity in both patients with Parkinson disease (PD) and normal controls was studied in the way of applying fluorescence polarization technique and serum lipid peroxide (LPO) was ascertained by thiobarbituric acid (TBA) colorimetry.The results showed that erythrocyte membrane microviscosity and LPO in patients with PD were significantly higher than the normal controls,and there was a positive relationship between them. These results suggest testing fluidity of the erythrocyte membrane may be useful for understanding of the damaged condition of all cells in the patients with PD. |
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| Keywords: | Parkinson disease Fluidity of menbrane Membrane microviscosity Lipid peroxide |
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