DWI、IVIM参数与脑胶质瘤患儿肿瘤标志物水平相关性

目的 探究扩散加权成像(diffusion weighted imaging, DWI)、体素不相干运动扩散加权成像(diffusion-weighted imaging of voxel incoherent motion, IVIM)参数与脑胶质瘤患儿肿瘤标志物水平相关性及诊断价值。方法 选取于我院进行诊断的疑似脑胶质瘤患儿89例，以病理检查为金标准，最终确诊脑胶质瘤患儿62例为观察组，其余27例为对照组。所有研究对象均进行DWI技术、IVIM技术检查，酶联免疫吸附实验法检测糖链抗原125(carbohydrate antigen 125,CA125)、表皮生长因子(epidermal growth factor, EGF)、癌胚抗原(carcinoembryonic antigen, CEA)水平，对比不同病情患儿表观弥散系数(apparent dispersion coefficient, ADC)、相对脑血容量(relative cerebral blood volume, rCBV)、真实水分子弥散系数(true water molecular dispersion coe...

Correlation of DWI and IVIM parameters with tumor marker levels in children with gliomas

ObjectiveTo investigate the correlation of diffusion-weighted imaging (DWI), and intravoxel incoherent motion diffusion-weighted imaging (IVIM) parameters with tumor marker levels in children with glioma and their diagnostic value.MethodsA total of 89 children with suspected glioma diagnosed in our hospital were selected. With pathological examination as the gold standard, 62 children with definitive diagnosis of glioma were selected as the observation group, and the remaining 27 children were selected as the control group. All subjects were examined by DWI and IVIM, and the levels of carbohydrate antigen 125 (CA125), epidermal growth factor (EGF) and carcinoembryonic antigen (CEA) were detected by enzyme-linked immunosorption assay (ELISA). The levels of apparent dispersion coefficient (ADC), relative cerebral blood volume (rCBV), true water molecular dispersion coefficient (D), perfusion related dispersion coefficient (D*), CA125, EGF and CEA levels were compared in children with different conditions. The correlation between each indicator and the disease type was compared. The correlation between DWI, IVIM parameters and tumor markers in children with glioma was compared. The diagnostic value of DWI and IVIM parameters in glioma was analyzed.ResultsCompared with the control group, the ADC value and D parameters of the observation group were higher, while the rCBV and D* parameters were lower (P＜0.05). Compared with children with low-grade glioma, children with high-grade glioma had higher ADC values, D parameters and serum CA125, EGF and CEA levels, but lower rCBV and D* parameters (P＜0.05). The levels of rCBV and D* were negatively correlated with the type of disease (r=-0.395, P＜0.001; r=-0.405, P＜0.001), while ADC value, D, CA125, EGF, CEA levels were positively correlated with disease type (r=0.432, P＜0.001; r=0.441, P＜0.001; r=0.432, P＜0.001; r=0.409, P＜0.001; r=0.431, P＜0.001); ADC value (r=0.409, P＜0.001; r=0.415, P＜0.001; r=0.423, P＜0.001); D parameter was positively correlated with the levels of tumor markers CA125, EGF and CEA (r=0.417, P＜0.001; r=0.43, P＜0.001; r=0.409, P＜0.001); RCBV was negatively correlated with the levels of tumor markers CA125, EGF and CEA (r= -0.402, P＜0.001; r=-0.413, P＜0.001; r=-0.387, P＜0.001); D* level was negatively correlated with the levels of tumor markers CA125, EGF and CEA(r=-0.411, P＜0.001; r=-0.406, P＜0.001; r=-0.399, P＜0.001). Compared with ADC value, rCBV, D and D *, the combined detection of the four indicators was more effective in the diagnosis of glioma (P<0.05).ConclusionDWI and IVIM parameters have certain correlation with tumor markers in children with glioma, and have certain diagnostic value for the disease types of children with glioma.