慢性阻塞性肺疾病患者细胞因子与动脉血气间的相关性研究

目的 研究探讨COPD患者血清IL-8、CK-MB的含量与动脉血气变化的相互关系.方法 A组(COPD伴有呼衰)62例患者及B组(COPD不伴有呼衰)63例患者,测定其患者治疗前后血清IL-8、CK-MB和PaO2、PaCO2的含量.结果 治疗前A组血清IL-8、CK-MB含量明显高于B组(P＜0.01),治疗后A组血清IL-8、CK-MB较治疗前明显下降(P＜0.0l)；治疗前A组PaO2明显低于B组,且PaCO2明显高于B组(均P＜0.01)；治疗后A组PaO2明显高于治疗前,且PaCO2明显低于治疗前(均P＜0.01)；治疗前后B组及治疗后A、B两组PaO2、PaCO2比较无显著性差异(P＞0.05).结论 COPD患者合并缺缺O2、CO2潴留时,细胞炎性因子可显著升高,可伴心肌损害,心肌收缩力减弱而导致心衰.

Study on the relation between serum cytokine and arterial blood gas in patients with Chronic Obstructive Pulmonary Diseasenary Disease

Objective To explore the relation between IL-8,CK-MB and arterial blood gas in patients with Chronic obstructive pulmonary disease.Methods 62 cases of Chronic obstructive pulmonary disease with respiratory failure was enrolled into group A and 63 cases of Chronic obstructive pulmonary disease without respiratory failure was enrolled into group B.The concentrations of serum IL-8,CK-MB PaO2 and PaCO2 were measured before and after treatment.Results The concentrations of serum IL-8,CK-MB in group A were significantly higher than those in group B before treatment(P<0.01);the concentrations of serum IL-8,CK-MB of the patients significantly decreased in group A after treatment(P<0.01);The PaO2 of patients of group A was significantly lower than that of patients of group B,and the PaCO2 of patients of group A was significantly higher than that of patients of group B before treatment(P<0.01);The PaO2 in patients of group A after treatment was significantly higher than that before treatment,and the PaCO2 in patients of group A after treatment obviously lower than that before treatment(P<0.01);The PaO2 of patients in group B before and after treatment,and the PaCO2 in patients between A and B after treatment were compared without significance differences(P>0.05).Conclusion Patients of COPD with hypoxia and retention of carbon dioxide can significantly increase cell inflammatory factor,complicated with myocardial injury.In the end,cardiac muscle systole decrease can result in heart failure.