非霍奇金淋巴瘤环氧合酶-2和血管内皮生长因子蛋白的表达及其相关性

 目的　探讨环氧合酶-2（COX-2）和血管内皮生长因子（VEGF）在非霍奇金淋巴瘤（NHL）的表达及其相关性。方法　用免疫组织化学法检测28例NHL患者COX-2和VEGF的表达,以22例良性淋巴结病变标本作为对照。结果　COX-2和VEGF在NHL中的阳性表达率分别为82.1 %（23／28）和78.6 %（22／28）,明显高于对照组（P＜0.01）。COX-2和VEGF在NHL中的表达呈正相关（χ2＝10.50,P＜0.01）。结论　COX-2和VEGF在NHL组织高表达且正相关,表明二者可能具有共同的作用途径,COX-2抑制剂有望成为新的治疗药物。

Expression of COX-2 and VEGF in non - Hodgkin lymphoma and its clinical significance

Objective To investigate the expression and significance of COX-2 and VECF in NHL Methods The expression of COX-2 and VECF in 28 cases of NHL was detected by immunohistochemistry, and 22 patients with benign lymphadenopathy were chosen as controls. Results Positive rates of COX-2 and VEGF were 82.1 %(23/28) and 78.6 %(22/28) in NHL respectively, significantly higher than that in the control (P <0.01). The expression rate of COX-2 was positively correlated with that of VEGF in tissues of NHL (χ~2 =10.50, P<0.01). Conclusion The expression of COX-2 and VEGF are high in NHL COX-2 and VEGF might have a common induction pathway, and selective COX-2 inhibitor might be a new drug for treatment of NHL in the future.