大剂量静脉应用美托洛尔抢救急性主动脉夹层的疗效观察

目的：观察静脉滴脉注超大剂量美托洛尔抢救急性主动脉夹层的，临床疗效。方法：对23例急性主动脉夹层患者随机分为A组12例、B组11例，A组采用美拉洛尔治疗，B组不用，比较A、B两组治疗前、后血压，心率变化情况。结果：两组治疗前血压及心率差异无统计学意义（P〉0．05）；A组治疗后收缩压、舒张压、心率均较B组明显改善，住院时间较B组明显缩短，死亡率较B组明显降低（均P〈0．05）。结论：大剂量静脉应用美托洛尔是抢救急性主动脉夹层一种安全有效的治疗方法。

Effect of intravenous drip of metoprolol at large dosage on rescuing acute aortic dissection

Objective:To observe effect of intravenous drip of metoprolol at large dosage on rescuing acute aortic dissection.Methods:Randomly divided 23 cases with acute aortic dissection into A and B groups.Treated patients in group A with metoprolol,but no metoprolol in group B.Compared the change of blood pressure and heart rate before and after therapy in two groups.Results:There was no statistic significant change of blood pressure and heart rate in both groups(P>0.05).Comparing with group B,systolic pressure,diastolic pressure and rate in group A were improved after treatment,the hospitalization time shortened obviously and the mortality decreased markedly.Conclusion:Intravenous drip of metoprolol at large dosage is effective and safe in rescuing acute aortic dissection.