男性非酒精性脂肪性肝病患者血糖波动研究

选取48例糖耐量正常男性为研究对象，其中非酒精性脂肪性肝病23例为病例组，无脂肪肝25例为对照组，应用动态血糖监测系统评价血糖波动情况。结果显示，病例组平均血糖波动幅度[MAGE，（2.17±1.13对1.45±0.42）mmol/L]和血糖标准差[SDBG，（0.88±0.45对0.61±0.21）mmol/L]均高于对照组(P＜0.05)。MAGE和SDBG与体重指数、腰围和糖负荷后0.5h血糖升高值(AG30)呈正相关(均P＜0.05)。以MAGE为因变量，行多元线性回归分析显示，△G30、腰围和年龄被引入方程(P＜0.05或P＜0.01)。以SDBG为因变量，行多元线性回归分析显示，AG30和腰围被引入方程（P＜0.05或P＜0.01）。

Analysis on blood glucose excursion in men with nonalcoholic fatty liver disease

Forty-eight men with normal glucose tolerance were divided into fatty liver disease ( NAFLD, n =23 ) and non-NAFLD (n =25 ) groups. The blood glucose excursion was evaluated by continuous glucose monitoring system. The results showed that the mean amplitude of glucose excursion[MAGE, (2. 17± 1.13 vs 1.45±0. 42 )mmol/L]and standard deviation of blood glucose[SDBG, (0. 88 ±0. 45 vs 0. 61 ±0. 21 ) mmol/L]were significantly higher in NAFLD group than in non-NAFLD group( both P＜0. 05 ). MAGE and SDBG were positively correlated with body mass index, waist circumference, and the increased value of plasma glucose 0. 5 h after glucose loading( △G30,all P＜0. 05 ). In multiple regression analysis, △G30, waist circumference, and age were significant independent predictors for MAGE( P＜0. 05 or P＜0. 01 ). △G30 and waist circumference were significant independent predictors for SDBG( P＜0. 05 or P＜0. 01 ).