早期静注甲钴胺联合针灸治疗对脑梗死伴高同型半胱氨酸患者预后的影响

目的探讨早期静注甲钴胺联合针灸治疗对脑梗死伴高同型半胱氨酸患者预后的影响。方法选取韶关市粤北人民医院2010年10月～2012年10月收治的脑梗死伴高同型半胱氨酸患者83例,随机分为两组,41例患者实施常规治疗为对照组,42例患者实施早期静注甲钴胺联合针灸治疗为观察组,随访3个月,比较两组患者治疗前后同型半胱氨酸水平、瘫痪侧肢体运动功能评分、临床疗效、不良反应情况。结果治疗后,两组患者同型半胱氨酸水平均显著下降,瘫痪侧肢体运动功能评分均显著升高。观察组同型半胱氨酸水平（10.6±4.2）μmol/L]明显低于对照组（18.4±3.9）μmol/L],观察组瘫痪侧肢体运动功能评分（91.4±5.7）分]明显高于对照组（73.1±6.9）分],观察组总有效率（97.6%）明显高于对照组（78.0%）,观察组不良反应发生率（4.8%）明显低于对照组（19.5%）,差异有统计学意义（P〈0.05）。结论早期静注甲钴胺联合针灸是治疗脑梗死伴高同型半胱氨酸的有效方法,可明显降低患者同型半胱氨酸水平,改善肢体运动功能,临床疗效显著且安全性较高,值得临床推广使用。

Prognostic impact of early intravenous injection Mecobalamin combined with acupuncture in the treatment of patients with cerebral infarction and high HCY

Objective To investigate prognostic impact of early intravenous injection Mecobalamin combined with acupuncture in the treatment of patients with cerebral infarction and high HCY.Methods 83 patients with cerebral infarction and high HCY were selected in Yuebei People＇s Hospital of Shaoguan City from October 2010 to October 2012,who were randomly divided into two groups.41 patients who received routine treatment were as control group.42 patients who received early intravenous injection Mecobalamin combined with acupuncture treatment were as ob servation group.Patients were followed up for 3 months.HCY levels before and after treatment,paralyzed limbs motor function score,clinical efficacy,adverse reactions of patients were compared between two groups.Results After treatment,HCY levels in two groups decreased significantly,while paralyzed limbs motor function score increased signifi cantly.HCY level （10.6±4.2） μmol/L] in observation group was significantly lower than control group （18.4±3.9） μmol/L].Paralyzed limbs motor function score （91.4±5.7） points] in observation group was significantly higher than control group （73.1±6.9） points].Total effective rate in observation group（97.6%） was significantly higher than control group（78.0%）.Incidence of adverse reactions in observation group（4.8%） was significantly lower than control group（19.5%）.Differ ence was statistically significant（P 0.05）.Conclusion Early intravenous injection Mecobalamin combined with acupuncture are effective methods for treatment of cerebral infarction and high HCY,which can decrease HCY level and im prove motor function of limbs.That has significant clinical effect and high security.That is worthy of clinical use.