国产丹参药材质量评价研究

 目的综合考察国产丹参药材质量。方法用HPLC测定了21批产地样品、9批市售样品丹参药材中丹酚酸B、丹参酮ⅡA等7种指标成分含量,并考察了水溶性浸出物、醇溶性浸出物、醚溶性浸出物、总灰分、酸不溶性灰分及水分等药材常规理化实验项目。结果丹参药材中丹酚酸B为水溶性成分的主体,丹参酮Ⅱ_A为脂溶性成分的主体,丹参药材指标成分含量和常规实验项目测定结果显示:不同产地丹参药材间品质差异较大,且不同干燥法对丹参7种指标成分含量有较大影响。结论本研究为国产丹参药材综合质量评价提供理论和实验依据。

Studies on Systematical Quality Evaluation of Salvia miltiorrhiza planted in China

OBJECTIVE To systematically evaluate the quality of Salvia miltiorrhiza planted in China.METHODS The contents of 7 marker compounds in 30 samples of Salvia miltiorrhiza collected from different cultivated farms and markets were analysed by HPLC method.Some physical and chemical tests (H₂O extract,EtOH extract,Et₂O extract,total ash,acid-insoluble ash,H₂O)were done to investigate their quality.RESULTS Salvianolic acid B was a predominant phenolic constituent and tanshinone Ⅱ_A was the main lipophilic constituent in the crude drug material.There were significant differences in contents of 7 marker compounds as well as some physical and chemical parameters.And the contents of phenolic constituents were affected by different processing method.CONCLUSION The study provided theory and experimental data in order to systematically evaluate the quality of Salvia miltiorrhiza planted in China.