肾素-血管紧张素系统基因多态性与冠心病合并慢性心力衰竭严重程度的关系

目的检测部分中国南方汉族人群冠心病合并慢性心力衰竭患者的ACE及AGT基因多态性分布情况，以探讨肾素-血管紧张素系统（1／AS）基因多态性对冠心病合并慢性心力衰竭严重程度的影响。方法应用聚合酶链反应及限制性片断长度多态性技术，对210例冠心病合并慢性心力衰竭患者的ACE基因插入／缺失（I/D）及AGT基因M235T多态性进行检测，采用彩色多普勒检测患者的左室舒张末内径（LVDD）及左室射血分数（LVEF）。结果不同ACE基因型患者其LVDD及LVEF均存在差异，LVDD（DD）〉LVDD（ID）〉LVDD（II）（P〈0．05），LVEF（DD）〈IXEF（ID）〈LVEF（II）（P〈0．05），不同AGT基因型亚组间LVDD及LVEF差别均无统计学意义（P〉0．05）。结论ACE基因I／D多态性与中国南方部分汉族人群冠心病合并慢性心力衰竭的严重程度相关，DD型ACE基因的冠心病患者发生心力衰竭后病情较其他基因型者更加严重。AGT基因M235T多态性似与冠心病合并慢性心力衰竭的严重程度无关。

Associated study between renin-angiotensin system gene polymorphisms and the severity of ischemic chronic heart failure

Objective To investigate the relationship between angiotensin-converting enzyme（ACE）g erie insertion/deletion （I/D） and angiotensinogen （AGT） gene M235T polymorphism and the prognosis of ischemie chronic heart failure （CHF） in South Chinese people. Methods ACE gene I/D and AGT gene M235T polymorphisms were analyzed in 210 consecutive patients with ischemic CHF, the gene polymorphisms were detected by polymerase chain reaction and restriction fragment length polymorphism methods. Left ventricular end diastolic di- mension （LVDD） and left ventricular ejection fraction （LVEF） were measured by Color Doppler Sonography. Results There was statistics significance in LVDD and LVEF in different subsets of ACE gene, LVDD （DD）〉 LVDD（ID）〉LVDD（II）（P〈0.05）, LVEF（DD）〈LVEF（ID）〈LVEF（II）（P〈0.05）, LVDD and LVEF between three genotypcs of AGT gene have no statistics significance. Conclusions ACE gene polymorphism is associated with the severity of pathogenetic condition of CHF in CAD patients. DD genotype may be a marker of poor progno- sis in patients with CHF. There is no relation between AGT gene polymorphism and the severity of CHF.