儿童肥胖症与瘦素相关因素的研究进展

儿童肥胖症作为一种多因素疾病 ,是遗传物质与环境因素相互作用的结果 ,它与成人期的发病率及死亡率密切相关。因此 ,人们需要制定出更有效的策略来辨识儿童期肥胖的危险因素和它们在儿童期肥胖形成过程中所起的作用。肥胖基因产生的瘦素 ,曾一度为治愈儿童肥胖症带来了曙光。瘦素是一种特殊蛋白质 ,绝大多数由白色脂肪细胞分泌入血液循环 ,人们认为它与从脂肪贮存到下丘脑之间的负反馈有关。在动物研究中 ,瘦素被发现在增加饱腹感与能量消耗上起作用 ,但人类的瘦素抵抗作用使得利用瘦素治疗儿童肥胖症成为难题。该文就儿童肥胖症与瘦素相关因素的研究进展作以综述

Advancement in research on relationship between childhood obesity and leptin

As a multifactorial disease, the development of childhood obesity is a result of interactions between genes and environmental factors. It has been proved to be associated with morbidity and mortality in adulthood, and is endangering human health greatly. Identification of obesity risk factors and their roles in development of excess fat deposit in childhood is therefore necessary in order to plan more successful strategies. The ob gene that produces leptin was identified by Zhang et al. firstly (1994), which seems hopeful to cure childhood obesity. Leptin, a specific protein, is secreted mostly by white adipocytes into the circulation and is believed to be involved in negative feedback loop from adipose storage to hypothalamus. In animal experiments, leptin has been found to have a role in increasing satiety and energy expenditure. But leptin resistance in human being makes it difficult to cure childhood obesity with leptin. This article reviewed advancement in research on relationship between childhood obesity and leptin.