Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells |
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Authors: | M Bianchi A Mantovani A Erroi C A Dinarello P Ghezzi |
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Affiliation: | Laboratory of Immunology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. |
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Abstract: | We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 microgram ml, without any apparent toxicity. |
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