| 口腔黏膜下纤维性变S100蛋白表达 |
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| 引用本文： | 谢晓莉,唐瞻贵,姚志刚,蒋海鹰.口腔黏膜下纤维性变S100蛋白表达[J].中南大学学报(医学版),2003,28(4):388-390. |
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| 作者姓名： | 谢晓莉 唐瞻贵 姚志刚 蒋海鹰 |
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| 作者单位： | 1. 中南大学湘雅医院口腔科,长沙,410008
2. 中南大学湘雅医学院病理科,长沙,410078 |
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| 基金项目： | 湖南省科技厅社会发展基金资助课题 (0 2SSY30 5 9) |
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| 摘 要： | 目的 :研究口腔黏膜下纤维性变中S10 0蛋白的表达水平及其与正常口腔黏膜上皮、异常增生上皮的比较。方法 :应用免疫组织化学 (SP)法 ,检测 10例口腔黏膜下纤维性变、10例上皮异常增生、8例正常口腔黏膜上皮S10 0蛋白表达水平 ,并作对比研究。结果 :S10 0蛋白在正常口腔黏膜上皮中无表达 ,口腔黏膜下纤维性变上皮中和异常增生上皮中S10 0的阳性表达率为 5 0 %,后两者的阳性表达率明显高于正常黏膜组上皮 (P <0 .0 5 ) ;口腔黏膜下纤维性变组与异常增生上皮组比较 ,差异无显著性 (P >0 .0 5 )。结论 :口腔黏膜下纤维性变发生发展与S10 0蛋白过表达密切相关 ,S10 0蛋白表达强度与异常增生上皮表达强度一致。
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| 关 键 词： | 口腔黏膜下纤维性变 S100 上皮异常增生 |
| 文章编号： | 1000-5625(2003)04-0388-03 |
| 修稿时间： | 2002年10月8日 |
Expression of S100 in oral submucose fibrosis |
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| XIE Xiao-li,TANG Zhan-gui,YAO Zhi-gang,et al..Expression of S100 in oral submucose fibrosis[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2003,28(4):388-390. |
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| Authors: | XIE Xiao-li TANG Zhan-gui YAO Zhi-gang |
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| Institution: | Department of Stomatology, Xiangya Hospital,Central South University, Changsha 410008,China) |
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| Abstract: | Objective To study the expression of S100 in oral submucose fibrosis(OSF).Methods Immunohistochemistry assay was performed on 10 cases of OSF,10 cases of oral epithelial dysplasia(OED) and 8 cases of normal oral epithelium using monoclonal antibody against S100 protein.Results S100 did not express in the normal oral muscosal epithelium.The S100 positive nuclear staining was found in 50% of the OSF and OED cases,which was significantly higher than that in the normal oral epithelium (P<0.05). But the positive staining in the OSF and OED cases had no difference (P> 0.05).Conclusion S100 expression is closely related to the development of OSF and OED.The positive staining expression in the OSF and OED cases is the same. |
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| Keywords: | oral submucose fibrosis S100 dysplasia |
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