恶性胸膜间皮瘤的治疗现状

恶性胸膜间皮瘤(MPM)是一种罕见的恶性肿瘤。外科手术是治疗的主要方式,术后辅助放疗能控制肿瘤的局部复发,并延长生存期。单纯放疗仅用于减症及预防有创性诊断后的局部种植。辅助化疗的作用不确切。化疗对晚期MPM有一定的作用,阿灵达与顺铂的联合应用将化疗的有效率从20%提高至40%以上,并能改善存活率、疾病进展时间和生活质量等,为该病的治疗带来了希望。应该继续开发新的靶向治疗药物,使MPM的治疗取得更多进展。

Current status in treatment of malignant pleural mesothelioma

Malignant pleural mesothelioma(MPM)represents a rare disease.The treatment is primarily surgical resection with a margin of normal tissue.Postoperative adjuvant radiotherapy improved local control and prolonged life span.Radiotherapy alone may palliate symptom and prevent local implantation after the diagnositic action.The role of chemotherapy in the adjuvant setting remains controversial.Chemotherapy has some effects on the local advanced or metastatic MPM.The combination of Alimita and cisplatin,which demonstrated a positive benefit on multiple outcomes including survival,time-to-progressive disease,and quality of life,has improved the effective power of chemotherapy from 20% to 40% at least and provided renewed hope for the treatment of this disease.Continued research on novel molecular targets and their respective targeted therapies will be very important for further advances to occure in the treatment of this disease.