Characterization of monoclonal antibodies to human Ia antigens

A set of monoclonal antibodies reacting with human Ia antigens is characterized. All of these antibodies (BL-Ia/1-3) have the same binding pattern to different types of leukocytes and a set of lymphoid and myeloid cell lines. Monoclonal antibody BL-Ia/1 can be used for complement dependent cytolysis of B cells and Ia+-T cells.