| 人参皂甙对老龄大鼠大脑皮质AChE老龄性改变的影响 |
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| 引用本文： | 高杰,赵海花,赖红,高旭红,李兆圣,吕永利.人参皂甙对老龄大鼠大脑皮质AChE老龄性改变的影响[J].解剖科学进展,2009,15(1):97-99. |
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| 作者姓名： | 高杰 赵海花 赖红 高旭红 李兆圣 吕永利 |
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| 作者单位： | 中国医科大学解剖教研室,辽宁,沈阳,110001 |
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| 基金项目： | 辽宁省自然科学基金，辽宁省教育厅资助项目 |
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| 摘 要： | 目的观察大鼠大脑皮质乙酰胆碱酯酶(AChE)阳性纤维的老龄性改变,探讨人参皂甙对其影响。方法24只雌性Wis青tar大鼠随机分为青年组、老龄组及给予人参皂甙的给药组。对各组大鼠大脑皮质进行AChE酶细胞化学染色,图像分析各组大鼠大脑皮质神经纤维AChE含量及AChE纤维的配布情况。结果老龄组大鼠大脑皮质神经纤维AChE平均光密度值较年组明显减少(p<0.01),AChE纤维面积百分比例下降,人参皂甙组大鼠大脑皮质神经纤维AChE平均光密度值较老龄组明显增加(p<0.01),纤维面积百分比例上升。结论人参皂甙可增加老龄大鼠大脑皮质纤维中AChE平均光密度值,促进纤维侧枝出芽和纤维网的生长及重建。
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| 关 键 词： | 大脑皮质 乙酰胆碱酯酶 人参皂甙 老龄大鼠 酶细胞化学染色 |
Effect of Ginseng Total Saponins on the Expression of Acetylcholinesterase in Cerebral Cortex of Aged Rats |
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| GAO Jie,ZHAO Hai-hua,LAI Hong,GAO Xu-hong,LI Zhao-sheng,Lü Yong-li.Effect of Ginseng Total Saponins on the Expression of Acetylcholinesterase in Cerebral Cortex of Aged Rats[J].Progress of Anatomical Sciences,2009,15(1):97-99. |
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| Authors: | GAO Jie ZHAO Hai-hua LAI Hong GAO Xu-hong LI Zhao-sheng Lü Yong-li |
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| Institution: | Department of Anatomy;China Medical University;Shenyang 110001 China |
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| Abstract: | Objective To study the effect of ginseng total saponins(ginsenosides,GS) on the expression of acetylcholinesterase(AChE) in cerebral cortex of aged rats.Method 24 female Wistar rats were randomly divided into young group,aged groups and GS-treated group.Enzyme cytochemical staining was used to show the AChE fibers in cortex.Imaging analysis was used to analysis AChE expression and distribution of AChE fibers in 3 groups.Result Average optic density(AOD) and area of AChE positive products were significantly ... |
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| Keywords: | cerebral cortex acetylcholinesterase ginsenosides aged rats enzyme cytochemical staining |
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