| 光化学诱导的血栓形成性脑缺血及其代谢改变 |
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| 引用本文： | 李树清 叶冀明. 光化学诱导的血栓形成性脑缺血及其代谢改变[J]. 中国病理生理杂志, 1994, 10(1): 95-99 |
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| 作者姓名： | 李树清 叶冀明 |
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| 作者单位： | 昆明医学院病理生理教研室，昆明医学院实验中心分析测试室 |
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| 摘 要： | 本文用光化学法激发大鼠局部脑血栓形成，以组织病理学、局部脑血流量、皮层水含量、三磷酸腺苷、二磷酸腺苷，一磷酸腺苷、能量负荷、肌酸及乳酸为指标，探讨局部脑血栓形成后５天ｒＣＢＦ明显增高的可能机理。结果表明，血栓形成后局部脑组织ＡＴＰ水平进行性减少（Ｐ＜０．０１）、ＡＤＰ／ＡＴＰ及ＡＭＰ／ＡＴＰ比值明显升高（Ｐ均＜０．０１），ＬＡ及脑水含量显著增加（Ｐ＜０．０１）。这些因素既是能量衰竭、无氧酵解的结果
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| 关 键 词： | 光化学 血栓形成 脑缺血 能量代谢 |
Photochemically induced thrombotic cerebral ischemia and its metabolic alterations |
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| Li Shu-Qing,Yang Qiong-Yin,et al. Photochemically induced thrombotic cerebral ischemia and its metabolic alterations[J]. Chinese Journal of Pathophysiology, 1994, 10(1): 95-99 |
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| Authors: | Li Shu-Qing Yang Qiong-Yin et al |
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| Affiliation: | Li Shu-Qing,Yang Qiong-Yin,et al Department of Pathophysiology,Kunming Medical College,Kunming |
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| Abstract: | Photochemically initiated regional thrombosis in rat brain hasbeen perfor-med. The histopathology, regional cerebral blood flow (rCBF) , brain water content, ATP,ADP,AMP, energy charge (EC), creatine (Cr) and lactate(LA) in cortex were used asindexes, The possible mechanism of rCBF increasing which occured at 5 days following cere- bral thrombosis was discussed. The results showed that ATP level in the brain decreased progressively(P<0.01),ADP/ATP and AMP/ATP ratio increased markedly (P<0.01). Brain lactate and water content in the ischemic area increasedignificantly(P<0 .01).These facts were not only the results of energy failure and anaerobic glycolysis but wasalso the cause of post-ischemic brain damage. The mechanism of increased rCBF following cerebral thrombosis might be associated with increased adenosine and lactate content. |
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| Keywords: | photochemistry Thrombosis Regional cerebral blood folw Energy metabloism Brain edema Lactates Adenosine |
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