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| 异搏停和山莨菪碱对大鼠被动型Heymann肾炎病变的影响 | |
| 引用本文： | 王迎伟 郝兴芝. 异搏停和山莨菪碱对大鼠被动型Heymann肾炎病变的影响[J]. 中国病理生理杂志, 1994, 10(3): 310-313 |
| 作者姓名： | 王迎伟 郝兴芝 |
| 作者单位： | 徐州医学院免疫病理室 |
| 摘 要： | 本实验应用抗大鼠肾小管抗原的抗血清制做大鼠被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）动物模型，并选用异搏停和山莨菪碱进行处理，观察两药对其病变的影响，结果表明：异搏停及山莨菪碱处理的大鼠尿蛋白均明显低于ＰＨＮ组，病理组织损伤亦有一定程度的改善。提示：上述两药均对大鼠ＰＨＮ病变有一定的治疗作用。 |
| 关 键 词： | 肾炎 维拉帕米 山莨萱碱 |
Effects of Verapamil and Anisodamine on pathologic changes of passive Heymann nephritis in rats |
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| Wang Ying-Wei,Hao Xing-Zhi,et al. Effects of Verapamil and Anisodamine on pathologic changes of passive Heymann nephritis in rats[J]. Chinese Journal of Pathophysiology, 1994, 10(3): 310-313 | |
| Authors: | Wang Ying-Wei Hao Xing-Zhi et al |
| Affiliation: | Wang Ying-Wei,Hao Xing-Zhi,et al Department of Immunopathology,Xuzhou Medical College,Xuzhou |
| Abstract: | An animal model of passive Heymann nephritis(PHN)in rats was madewith the antiserum against renal tubular antigen(Tub-Ag)of rats.Verapamil andAnisodamine were chosen to treat the rats with PHN and effects of these two drugson pathologic changes in PHN were observed.The results showed that proteinuria in grouptreated by Verapamil or Anisodamine was apparently lower than that in group ofPHN.The tissue injuries in groups treated by these two drugs were ameliorated to acertain extent.The results suggested that these two drugs had curative effects to thepathologic changes of PHN in rats. |
| Keywords: | Nephritis Verapamil Anisodamine |
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