半胱氨酸蛋白酶抑制剂C在糖尿病肾病中的诊断作用

目的探讨血清半胱氨酸蛋白酶抑制剂C（cystatin C）在诊断早期糖尿病肾病（DN）中的价值。方法测定糖尿病正常蛋白尿组（A组），糖尿病微量蛋白尿组（B组），糖尿病大量蛋白尿组（C组）的血清cystatin C和血尿素氮（BUN）、血清肌酐（Ser），对各项指标比较分析。结果cystatin C值C组明显高于B、A组，B组高于A组，cystatin C在三组之间差异均有统计学意义（P〈0．05）；BUN、Scr在A、B组中无显著性差异，但C组患者的BUN和Scr明显高于A、B组，差异有统计学意义（P〈0．05）。结论血清cystatin C是诊断早期DN的理想指标。

The diagnostic value of serum cystatin C in early stage diabetic nephropathy

Objective To explore the diagnostic value of serum cystatin C in early stage diabetic nephropathy. Methods Determination of diabetic normal albuminuria group （A）, diabetic microalbuminuria group （B group）, a large number of diabetic proteinuria group （C）, cystatin C serum blood urea nitrogen （BUN）, serum creatinine （Scr）, the various indicators Comparative analysis. Result Cystatin C value of the group C was significantly higher than group B and A, group B than group A. Cystatin C IN the three groups was statistically significant differences （ P 〈 0.05） ; BUN, Scr in the A, B group, no significant differences, but Group C with BUN and Scr were significantly higher than A, B group, the difference was statistically significant （ P 〈 0.05）. Conclusion Serum cystatin C in early diagnosis of diabetic kidney disease is the ideal targets.