D-二聚体测定在慢性阻塞性肺疾病中的意义

目的通过对慢性阻塞性肺疾病患者D-二聚体的检测,探讨其与疾病的关系与临床意义。方法统计慢性阻塞性肺疾病患者缓解期、加重期及加重期治疗前后D-二聚体水平。结果D-二聚体水平在慢性阻塞性肺疾病加重期患者明显升高,与对照组相比有显著性差异;治疗后D-二聚体明显下降;D-二聚体与动脉血氧分压（PaO2）呈负相关,与动脉血二氧化碳分压（PaCO2）呈正相关。结论监测慢性阻塞性肺疾病患者D-二聚体水平,并及时纠正缺氧、解痉及适当的给予抗凝药物治疗,有助于改善患者临床预后。

Significance of D-dimer Concentration Test in the Patients with Chronic Obstructive Pulmonary Disease

Objective To explore the significance and the association between variations of D--dimer and chronic obstructive pulmonary disease.Methods D--dimer content was determined in patients with chronic obstructive pulmonary disease.Results The plasma D--dimer level was apparently higher in exacerbated patients than in controls.After treatment,the plasma D--dimer level was significantly low.The plasma D--dimer level was negatively correlated with PaO2.The plasma D--dimer level was positively correlated with PaCO2.Conclusion Detection of the D--dimer content,improvement of hypoxemia,ventilation and the anti--coagulability medicine treatment are benefit for chronic obstructive pulmonary disease patients.