161例肝病患者败血症菌群分布及药敏分析

目的 了解我院肝病患者败血症的菌群分布及对常用抗生素的敏感性。方法 对4年来血培养阳性的肝病患者进行分析。结果 161例败血症患者共检出细菌175株。革兰阴性菌128株，占73．7％，其中大肠杆菌占28．6％；革兰阳性菌44株，占25．1％；真菌3株，占1．7％。结论 我院肝病患者败血症的主要病原菌为革兰阴性菌，治疗宜首选第3代头孢菌素，广谱β-内酰胺酶菌株应首选泰能。治疗革兰阳性菌的最佳抗生素为万古霉素。

Characteristics of pathogens spectrum and drugs resistance in 161 septicemic patients with liver disease

Objective To study the characteristic of pathogens spectrum and the incidence of resistance to commonly used antibiotic in septicemia patients with liver disease. Methods During the June 2000 to June 2004, the patients with liver disease and positive blood cultures were analysed.Results There were 161 patiens with bacteremia and 175 strains of pathogen were isolated from them. There were 128 strains of Gram-negative organisms(73.1%), 44 strains of Gram-positive organisms (25.1%), 3 strinas of fungi (1.8%).Conclusion Gram-negative was the main pathogen of bacteremia in this series. The third generetion cephalosporins should be consitdered as the first choice. Impenem-cilastain sodium should be used for the treatment of strins. Vancomycin is the best antibiotic for Gram-negative organisms.