Imaging and renal failure: from inflammation to fibrosis

Multiple chronic renal diseases evolve to end-stage kidney disease due to progressive renal tissue fibrosis at the level of the interstitium or glomeruli. Fibrosis often results from transformation of the extracellular matrix by cytokines and chemokines released by activated cells in the setting of recurrent episodes of acute inflammation. Newer techniques to image intrarenal inflammation and fibrosis are mandatory for the non-invasive evaluation of these processes to improve follow-up and monitoring of drug therapy. These techniques are based on methods of cellular and molecular imaging, and methods of functional, such as diffusion weighted imaging, and structural, such as elastography.