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Expert opinion: Responsive polymer nanoparticles in cancer therapy |
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| Authors: | William B. LiechtyNicholas A. Peppas |
| Affiliation: | a Department of Chemical Engineering, The University of Texas at Austin, TX, USA b Department of Biomedical Engineering, The University of Texas at Austin, TX, USA c College of Pharmacy, The University of Texas at Austin, TX, USA |
| Abstract: | Polymeric nanoparticles are emerging as an attractive treatment options for cancer due to their favorable size distribution, drug carrying capacity, and tunable properties. In particular, intelligent nanoparticles that respond to biological cues are of interest because of their ability to provide controlled release at a specific site. Tumor sites display abnormal pH profiles and pathophysiology that can be exploited to provide localized release. In this expert opinion, we discuss passive and active targeting of nanoparticles and several classes of pH-responsive nanoparticles. |
| Keywords: | Drug delivery pH-responsive polymers Cancer therapy Nanoparticles Nanogels Polymer micelles |
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