| 氧化苦参碱缓释片的制备及其体外释药动力学研究 |
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| 引用本文： | 万发里,邓树海,苗彩云.氧化苦参碱缓释片的制备及其体外释药动力学研究[J].中国药学杂志,2005,40(13):1002-1003. |
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| 作者姓名： | 万发里 邓树海 苗彩云 |
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| 作者单位： | 山东大学药学院药物制剂研究所,山东,济南,250012 |
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| 摘 要： | 目的制备氧化苦参碱缓释片剂,并评价其体外释药特性。方法以羟丙甲纤维素为缓释骨架材料,采用湿法制粒压片,制备氧化苦参碱缓释片,进行体外释放度实验,考察释放介质对释放度的影响。结果研制的氧化苦参碱缓释片具有明显的缓释作用,药物的体外释放符合一级动力学规律ln(100-Q)=-0.11t+4.50,r=0.09998]。结论该缓释片处方合理,制备工艺简单,达到了预期结果。
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| 关 键 词： | 氧化苦参碱 缓释片 羟丙甲纤维素 释放度 |
| 文章编号： | 1001-2494(2005)13-1002-03 |
| 收稿时间： | 2004-11-03; |
Sutdy on preparation and in vitro release of oxymatrine sustained-release tablets |
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| WAN Fa-li,DENG Shu-hai,MIAO Cai-yun.Sutdy on preparation and in vitro release of oxymatrine sustained-release tablets[J].Chinese Pharmaceutical Journal,2005,40(13):1002-1003. |
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| Authors: | WAN Fa-li DENG Shu-hai MIAO Cai-yun |
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| Institution: | College of Pharmacy，Shandong University，Jinan 250012，China |
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| Abstract: | OBJECTIVE To prepare oxymatrine sustained-release tablets and evaluate the drag release property.METHODS Oxyma-trine sustained-release tablets were prepared with HPMC by wetting granulating method. The release rates of the sustained-release tablets were determined and the effects of the release medium were investigated. RESULTS The prepared sustained-release tablets had an obvious sustained-release effect, and the drug release pattern folloloed the first order kineticsln(100- Q) =- 0.11t 4.50,r = 0.9998].CONCLUSION The sustained-release tablets reach the expectable results with its reasonable formulation and simple technology. |
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| Keywords: | oxymatrine sustained-release tablets HPMC release rate |
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