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| 血液中N-甲基氨甲酰加合物作为二甲基甲酰胺职业接触标志物可行性探讨 | |
| 引用本文： | 刘强,王春民,李建,姚建华,黄路,米凯,徐波. 血液中N-甲基氨甲酰加合物作为二甲基甲酰胺职业接触标志物可行性探讨[J]. 工业卫生与职业病, 2011, 0(5): 282-286 |
| 作者姓名： | 刘强 王春民 李建 姚建华 黄路 米凯 徐波 |
| 作者单位： | 苏州市疾病预防控制中心;湖南化工研究院;苏州太仓市疾病预防控制中心; |
| 基金项目： | 江苏省预防医学科研基金项目(Y200720); 江苏省卫生厅科研项目(H200866) |
| 摘 要： | 目的 探讨血液中N-甲基氨甲酰加合物作为二甲基甲酰胺(DMF)职业接触标志物可行性.方法 选择不同生产部门、不同DMF接触水平的职业人群87人,不接触DMF等有机溶剂的人员22人作为对照.气相色谱-质谱法测定N-甲基氨甲酰加合物经过一系列降解后的产物3-甲基-异丙基乙内酸脲(MVH)浓度.结果 各类DMF职业接触人员血... |
| 关 键 词： | 血液N-甲基氨甲酰加合物 二甲基甲酰胺 接触标志物 |
Feasibility Study on Taking Blood N-methylcarbamoyl Adduct as an Occupational Exposure Biomarker of DMF |
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| LIU Qiang,WANG Chun-min,LI Jian,YAO Jian-hua,HUANG Lu,MI Kai,XU Bo. Feasibility Study on Taking Blood N-methylcarbamoyl Adduct as an Occupational Exposure Biomarker of DMF[J]. Industrial Health and Occupational Diseases, 2011, 0(5): 282-286 | |
| Authors: | LIU Qiang WANG Chun-min LI Jian YAO Jian-hua HUANG Lu MI Kai XU Bo |
| Affiliation: | LIU Qiang,WANG Chun-min,LI Jian,YAO Jian-hua,HUANG Lu,MI Kai,XU Bo( Suzhou Center for Disease Control & Prevention,Suzhou 215004 China) |
| Abstract: | Objective To explore the feasibility of taking blood N-methylcarbamoyl adduct as an occupational exposure biomarker of DMF.Methods 87 workers occupationally exposed to DMF were taken as the experiment subjects.22 staff unexposed to DMF or any other organic solvents were taken as the controls.Concentration of MVH,the degeneration product of N-methylcarbamoyl adduct,was determined by GC-MS.Results In hemoglobin of DMF exposed workers,MVH in different concentrations was detected,but not in any one of the contr... |
| Keywords: | Blood N-methylcarbamoyl adduct DMF Exposure biomarker |
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