| The effect of calcium—antagonist on Bcl—2 and Bax mRNA expression fol—lowing ischemic brain injury |
| |
| 作者姓名： | 周瑞祥 刘昌勤 等 |
| |
| 作者单位： | [1]DepartmentofNeurology,XieheHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,HubeiProvince,China [2]DepartmentofNeurology,XieheHospital,TongjiMedicalCollege,HuazhongUnive |
| |
| 摘 要： | ![]()
AIM:In order to explore whether the member of Bcl-2 gene family,for exam-ple,Bcl-2 and Bax,are induced after cerebral ischemia,and whether expression of genes can be modulated by calcium-antagonist.METHODS:The rat cere-bral ischemic models were made by Nagassawa and Zea Longa improvement method,by occluding left middle cerebral artery;the expression of Bcl-2 and Bax mRNA were measured by RT-PCR method.RESULTS:After administra-tion of nimodipine,Bcl-2 mRNA was up-regulated in the hippocampus at 6 and 24 h after ischemia,while Bax mRNA was down-regulated at 6 and 24h after ischemia.CONCLUSION:Calcium-antagonist can up-regulate Bcl-2mRNA and down-regulate Bax mRNA .Increasing the ratio of Bcl-2 and Bax mRNA may contribute to the anti-apoptic effect of nimodipine.
|
| 关 键 词： | 钙拮抗剂 缺血性脑损伤 Bcl－2 Bax 基因表达 |
| 本文献已被 维普 等数据库收录！ |
|
