结核性胸膜炎胸液中纤维蛋白原含量对胸膜肥厚及粘连形成的影响

目的　探讨结核性渗出性胸膜炎胸腔积液纤维蛋白原含量与胸膜肥厚、粘连的关系。方法117例初治结核性渗出性胸膜炎患者按胸腔积液纤维蛋白原含量从低到高分为A、B、C 3组 ,治疗过程中和治疗后测定胸膜厚度 ,评估胸膜粘连发生率。结果 治疗过程中胸膜厚度 :A组与B组比较 (t=2 .5 7,P<0.05 )有显著性差异 ,A组与C组比较 (t=7.15 ,P<0 .0 1)有显著差异性 ,B组与C组比较 (t=2.46 ,P<0 .0 5 )有显著性差异 ;胸膜粘连发生率 :A组与B组比较 (χ²=3.5 1,P>0.05 )无显著性差异 ,A组与C组比较 (χ²=9.87,P<0 .01)有显著性差异 ,B组与C组比较 (χ²=4 .5 1,P<0 .0 5 )有显著性差异。治疗结束时胸膜厚度 :A组与B组比较 (t=1.4 5 ,P>0 .0 5 )无显著性差异 ,A组与C组比较 (t=3.4 6 ,P<0.01)有显著性差异 ,B组与C组比较 (t=2 .89,P<0 .0 1)有显著性差异 ;胸膜粘连发生率 :A组与B组比较 (χ²=0 .10 ,P>0 .0 5 )无显著性差异 ,A组与C组比较 (χ²=4 .36 ,P<0.05)有显著性差异 ,B组与C组比较 (χ²=7.4 9,P<0 .0 1)有显著性差异。结论 胸液纤维蛋白原含量可影响胸膜肥厚度与胸膜粘连发生率。

The role of fibrinogen concentration of pleural effusion relate with the developing of pleural thickness and adhesion in tuberculous pleurisy

Objective To investigate the relationship of concentration of pleural effusion in tuberculous exudative pleurisy with pleural thickness and adhesion.Methods 117 cases of primary tuberculosis pleurisy were divided into 3 groups (A、B、C) from low to high according to the content of fibrinogen concentration of pleural effusion.Pleural thickness were measured and the incidence rates of pleural adhesion were assessed during the course of treatment and after treatment.Results Pleural thickness indicators in the course of treatment:there was difference between group A and group B ( t=2.57,P<0.05 );there was significant difference between group A and group C ( t=7.15,P<0.01 );there was difference between group B and group C( t=2.46,P<0.05 ).The incidence rate of pleural adhesion in the course of treatment:there was no difference between group A and group B (χ²=3.51, P>0.05 );there was significant differencebetween group A and group C(χ²=9.87, P<0.01 );there was difference between group B and group C (χ²=4.51,P<0.05 ).Pleural thickness indicators after treatment:there was no difference between group A and group B ( t=1.45,P>0.05 );there was significant difference between group A and group C ( t=3.46,P<0.01 );there was signifcant difference between group B and group C ( t=2.89,P<0.01 );The incidence rate of Pleural adhesion after treatment:there was no differnce between group A and group B (χ²=0.10,P>0.05);there was difference between group A and group C(χ²= 4.36,P<0.05 );there was significant difference between group B and group C (χ²=7.49,P<0.01 ).Conclusion Pleural thickness and the incidence rate of pleural adhesion were effected by the content of the fibrin in pleural effusion.