Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method. |
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| Authors: | Sophie Limou,Cé dric Coulonges,Mario Foglio,Simon Heath,Gora Diop,Sigrid Leclerc,Thomas Hirtzig,Jean-Louis Spadoni,Amu Therwath,Gé rard Lambeau,Ivo Gut,Jean-Franç ois Zagury |
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| Affiliation: | CEA/Institut de Génomique, Centre National de Génotypage, 2 rue Gaston Crémieux, 91057 Evry, France. |
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| Abstract: | ![]()
Members of the secreted phospholipase A2 (PLA2) protein family can inhibit HIV-1 virus replication in vitro. To evaluate the impact of PLA2 gene polymorphisms on AIDS disease development, we studied 12 family members using SNPlextrade mark technology that permitted simultaneous typing of 70 tagging Single Nucleotide Polymorphisms (tagSNPs). The study utilized HIV-1 seropositive donors with slow progressor (n=168) or rapid progressor (n=54) status, plus 355 control subjects. All donors were Caucasian (total 577 individuals). Genetic associations yielded mainly 0.01
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| Keywords: | PLA2 AIDS Genomic Disease Progression Pathogenesis HIV Genetic association |
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