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| 库普弗细胞在酒精性肝病发病机理中的作用 | |
| 引用本文： | 周俊英,姚树坤. 库普弗细胞在酒精性肝病发病机理中的作用[J]. 国际消化病杂志, 2006, 26(1): 17-20 |
| 作者姓名： | 周俊英 姚树坤 |
| 作者单位： | 1. 河北医科大学第三医院感染科,050051 2. 河北医科大学第四医院消化科,050017 |
| 摘 要： | 库普弗细胞(KC)是肝内定居的巨噬细胞,由于其细胞表面存在多种受体,可被多种配体和激活剂激活,通过产生反应氧、细胞因子和炎症介质等贯穿于酒精性肝病的发病过程,控制KC的活化将有助于减轻或阻止酒精性肝病的肝脏病变。 |
| 关 键 词： | 库普弗细胞 酒精性肝病 氧化应激 内毒素 |
| 收稿时间： | 2004-12-06 |
| 修稿时间： | 2004-12-06 |
The role of Kupffer cells in the pathogeny of alcoholic liver disease |
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| ZHOU Jun-ying,YAO Shu-kun. The role of Kupffer cells in the pathogeny of alcoholic liver disease[J]. International Journal of Digestive Disease, 2006, 26(1): 17-20 | |
| Authors: | ZHOU Jun-ying YAO Shu-kun |
| Abstract: | Kupffer cells are resident macrophages of liver. Multi-receptors consisted in the surface of kupffer cells, thereby can be activised by ligands and activators me cells. They take part in the pathogenesis of alcoholic liver diseases by means of releasing reactive oxygen species, cytokines and mediators of inflammation . Depressing the activation of kupffer cells will improve and prevent alcohol-induced liver injury. |
| Keywords: | Kupffer cells Alcoholic liver disease Oxidative stress Endotoxin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |