神经元特异性烯醇化酶检测在小细胞肺癌预后中的价值

目的 评价化疗前后血清神经元特异性烯醇化酶（NSE）检测在非手术治疗小细胞肺癌（SCLC）患者中的预后价值。方法 收集1997年6月－2000年12月上海市肺科医院内科收治144例SCLC患者，均于化疗前（D1）和化疗后21d(D21)检测NSE水平，进行预后单因素和多因素分析。结果 144例患者中D1－NSE阳性98例，占68.1%；阴性46例，占31.9%。D210－NSE阳性57例，占39.6%；阴性87例，占60.4%；单因素分析D1－NSE和D21－NSE均是提示预后有价值的指标；但COX多因素分析时，只有D21－NSE是提示预后的独立指标。结论 D21－NSE是提示小细胞肺癌预后的独立指标，在临床上有较重要的应用价值。

The prognostic value of serum neuron specific enolase detection in small cell lung cancer

Objective To evaluate the prognostic value of NSE detection in small cell lung cancer. Methods 144 unresectable small cell lung cancer patients were eligible in the retrospective study. NSE was analyzed before chemotherapy and 21 days after chemotherapy using ELISA method. Results For D1-NSE, 98(68.1%) were NSE positive and 46(31.9%) were NSE negative; for D21-NSE, 57(39.6%) were NSE positive and 87(60.4%) were NSE negative. In univariate analysis, both D1-NSE and D21-NSE have prognostic significance. But in multivariate analysis only D21-NSE is an independent prognostic factor. Conclusion D21-NSE in small cell lung cancer is an independent prognostic factor and may be proposed for use in the clinic and research.