| 药物相互作用致心房颤动患者INR异常升高的病例分析及文献复习 |
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| 引用本文： | 孙云川,王昕,秦明照,王家伟.药物相互作用致心房颤动患者INR异常升高的病例分析及文献复习[J].临床药物治疗杂志,2013,0(3):48-50. |
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| 作者姓名： | 孙云川 王昕 秦明照 王家伟 |
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| 作者单位： | 孙云川 (首都医科大学附属北京同仁医院药剂科 北京 100730)； 王昕 (首都医科大学附属北京同仁医院药剂科 北京 100730)； 秦明照 (首都医科大学附属北京同仁医院干部医疗科 北京 100730)； 王家伟 (首都医科大学附属北京同仁医院药剂科 北京 100730)； |
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| 摘 要： | 患者女性,85岁,因房颤长期服用华法林,国际标准化比值(INR)1.6-2.5。患者因咽痛服用头孢氨苄片3d,停用2d后INR升至11.72,伴右上臂片状瘀斑。次日停用华法林,给予静脉滴注10mg维生素K1,INR降至2.6。2d后重启华法林治疗,INR1.6-2.5。应用华法林时如增加合并用药,要密切监测INR及出血情况,重视华法林的药物相互作用。患者教育对华法林的用药安全十分重要。
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| 关 键 词： | 华法林 头孢氨苄 药物相互作用 国际标准化比值 |
Case analysis of the abnormal rise in INR due to drug interaction and brief review on literature |
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| Sun Yun-chuan Wang Xin Qin Ming-zhao,Wang Jia-wei.Case analysis of the abnormal rise in INR due to drug interaction and brief review on literature[J].Clinical Medication JOurnal,2013,0(3):48-50. |
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| Authors: | Sun Yun-chuan Wang Xin Qin Ming-zhao Wang Jia-wei |
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| Institution: | 1 Department of pharmacy, 2 Department of Medicine, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, China |
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| Abstract: | An 85-year old woman had a history of long-term oral warfarin for atrial fibrillation, with INR range between 1.6 and 2.5. The patient had taken cephalexin for 3 days due to pharyngitis, INR increased to 11.72 two days afer withdrawl of cephalexin. Ecchymosis occurred at the right upper-arm. Warfarin was withdrawn next day and INR decreased to 2.6 after intravenous vitamin K1 （110mg）, Warfarin was restarted and INR was between 1.6 and 2.5. INR and bleeding should be monitored more intensely if increase in drug combination. Interaction of warfarin with other drugs should be given more attention. Patient＇s education is very important for safety of warfarin use. |
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| Keywords: | Warfarin Cephalexin Drug interaction INR |
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