养血固表法联合抗组胺药治疗慢性特发性荨麻疹

目的: 评价中医养血固表法联合抗组胺药治疗慢性特发性荨麻疹(CIU)的疗效及安全性。 方法: 将75名患者随机分为试验组35例和对照组40例,治疗组予玉屏风散合桃红四物汤联合盐酸西替利嗪片(标准剂量),对照组只予盐酸西替利嗪片,均连用30 d,观察2组在治疗前和治疗5,10,15,20,25,30 d的症状积分和治疗后的有效率,并对2组治愈患者进行2个月的复发情况随访。 结果: 随着治疗时间的延长,治疗组对症状积分的改善逐渐优于对照组,治愈率治疗组优于对照组(P<0.05),总有效率差异无统计学意义,治疗组治愈患者的复发率亦明显低于对照组(P<0.05),2组患者都未出现严重不良反应。 结论: 中医养血固表法联合抗组胺药可获得较单用抗组胺药更高和更稳定的疗效。

Nourishing Blood and Strengthening Qi Therapy Combined with Anti-hestamine Drugs for Chronic Idiopathic Uticaria

Objective: To evaluate the efficacy and safety of nourishing Blood and strengthening qi, a traditional Chinese medicine (TCM) therapy, combined with anti-hestamine drugs for the treatment of chronic idiopathic uticaria (CIU). Method: Seventy five cases were allocated randomly into a experiment group and a control one. Yuping Fengsan and Taohong Siwu Tang, two famous TCM decoctions representing the therapy, combined with Cetirizine Hydrochloride Tablets were given to the experiment group. Cetirizine Hydrochloride Tablets were solely issued to the control group. The duration of administration for both groups was 30 days. The symptom grades at the point of the 0, 5^th, 10^th, 15^th, 20^th, 25^th, and 30^th day and the efficacy rate after the 30 days administration were calculated. In addition, a 2-month follow-up towards the recovered cases was carried out. Result: The experiment group had better improvement on symptom grades than that of the controls along with the administration duration. For recovery rate, experiment group also had evident preponderance to controlled (P<0.05). The difference of general efficacy rate between two groups had no statistical significance. Combining TCM therapy also had a lower recurrence rate than that of applying sole western medicine (P<0.05). Both group showed no severe adverse effect during the trial. Conclusion: The nourishing blood and strengthening qi therapy in TCM combined with anti-hestamine drugs can help improving and stabilizing the efficacy when treating CIU.