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Stereotactic radiosurgery for brain metastases from malignant melanoma and the impact of hemorrhagic metastases
Authors:Kristine Bauer-Nilsen  Daniel M. Trifiletti  Ajay Chatrath  Henry Ruiz-Garcia  Eduardo Marchan  Jennifer Peterson  Byron C. May  Jason P. Sheehan
Affiliation:1.Pediatric and Adolescent Drug Development, Children and Young People’s Unit,The Royal Marsden NHS Foundation Trust – Paediatric Offices,Sutton,UK;2.Division of Clinical Studies and Cancer Therapeutics,The Institute of Cancer Research,Sutton,UK;3.Department of Pediatric and Adolescent Oncology, Gustave Roussy, UMR 8203, CNRS,Univ. Paris-Sud,Villejuif,France;4.Clinical Trials Unit, Pediatric Oncology Department,Hospital Infantil Universitario Ni?o Jesús,Madrid,Spain;5.Department of Pediatric, Adolescents and Young Adults Oncology,Institut Curie,Paris,France;6.Department of Pediatric Oncology,Vall d’Hebron Hospital,Barcelona,Spain;7.Department of Pediatric Clinical Trials and Department of Pediatric Neuro-Oncology,Institut Hématologique et d’Oncologie Pédiatrique,Lyon,France;8.Pediatric Oncology Unit,Fondazione IRCCS Istituto Nazionale dei Tumori,Milan,Italy;9.Department of Pediatric Oncology,Birmingham Children’s Hospital,Birmingham,UK;10.Department of Pediatric Oncology,Notthingham Children’s Hospital,Nottingham,UK;11.Université Paris Descartes,Paris,France;12.Pediatric Oncology Unit,Great Ormond Street Hospital for Children NHS Foundation Trust,London,UK;13.Department of Clinical Research, Gustave Roussy,Université Paris-Sud,Villejuif,France
Abstract:
Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the outcome of children and adolescents with CNS tumors participating in phase I trials within the Innovative Therapies for Children with Cancer (ITCC) consortium. Patients with solid tumors aged?
Keywords:
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