Localization of cloned mouse chromosome 7-specific DNA to lethal albino deletions

Mouse chromosome X- and 7-specific DNA fragments have been isolated from a recombinant DNA library enriched for X⁽⁷⁾ chromosome sequences. The library was enriched by flow sorting the X⁽⁷⁾ chromosome, a derivation of the Cattanach translocation, prior to library construction. A DNA fragment was found to be located in a region deleted in newborn mice doubly heterozygous for the two albino deletions c^3H and c^6H in chromosome 7. These chromosome-specific DNA fragments will be useful for studying X inactivation spreading in the X-autosome translocation (T(X;7)1Ct) and for investigating the developmental effects of the lethal albino deletions.