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| 盐酸洛美沙星滴耳剂稳定性研究 | |
| 引用本文： | 邢国胜 刘维军. 盐酸洛美沙星滴耳剂稳定性研究[J]. 中国药学杂志, 1997, 32(5): 284-287 |
| 作者姓名： | 邢国胜 刘维军 |
| 作者单位： | 天津医院，天津医科大学药学系 |
| 摘 要： | 目的:预测盐酸洛美沙星滴耳剂有效期，用以扩大洛美沙星的临床应用，增加耳科用药。方法:采用紫外分光光度法剧定制剂含重.用经典恒温法和Weibull概率法探讨其德定性。结果:紫外分光光度法测定制剂含量平均回收率为99.80% ,RSD为0.66%。经典恒温法预测本制剂在pH为5～6, 25 ℃ 贮存时有效期为5.16年，Weibull概率法预测其有效期为4.98年。结论:紫外分光光度法测定盐酸洛美沙星滴耳剂快速简便，精密度好，可靠性高。在无阳光直射条件下室温贮存本制剂稳定性好。 |
| 关 键 词： | 盐酸洛姜沙星 滴耳剂 稳定性 |
| 收稿时间： | 1996-07-24; |
Stability of lomefloxacin hydrochloride ear drops |
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| Xing Guosheng. Stability of lomefloxacin hydrochloride ear drops[J]. Chinese Pharmaceutical Journal, 1997, 32(5): 284-287 | |
| Authors: | Xing Guosheng |
| Affiliation: | ( Xing GS)，Wang Jucun (Wang JC)，Hu Wenduo ( Hu WD)，et a |
| Abstract: | OBJECTIVE: To predict the stability of lomefloxacin hydrochloride ear drops. METHODS: The drops were determined using UV spectrophotometry. Classical isothermal method and Weibull probability paper method were used to determine the stability of the ear drops. RESULTS: The average recovery of lomefloxacin from the ear drops was 99.80%, and the average relative standard deviation (RSD) was 0.66%. After using classical isothermal method and Weibull probability paper method, the shelf life of the lomefloxacin ear drops was 5.16 years and 4.98 years respectively. CONCLUSION: The analysis method of UV spectrometry was rapid and precise. Being stored away from direct sunlight, the stability of lomefloxacin ear drops is good. |
| Keywords: | lomefloxacin hydrochloride ear drops stability |
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