生物型硬脑膜补片修补大鼠全层腹壁缺损

目的 探讨运用生物型硬脑膜补片修补大鼠全层腹壁缺损的可行性,并与涤纶布补片修补比较.方法 分别采用脑膜建补片和涤纶布修补12对大鼠全层腹壁缺损,术后2、8、16周分批处死大鼠采集标本,观察创面感染情况、缺损愈合速度、缺损愈合组织的厚度、镜下病理情况.结果 脑膜建补片组大鼠无死亡,12例缺损全部修复成功.涤纶组大鼠死亡2例,10例缺损修复愈合.脑膜建补片组织愈合较快,镜下炎症反应较轻,但愈合组织厚度差异无统计学意义.结论 脑膜建补片能很好地诱导结缔组织增生,修复腹壁缺损.

Repair of abdominal wall defect by NormalGEN (ACTM) in rat models

Objective To investigate the feasibility and advantages of NormalGEN (ACTM) for abdominal wall repair in rat models compared to polyester surgical patch. Methods NonnalGEN and polyester surgical patch were used to repair the defect in 12 pairs of rats with abdominal wall defect. These 12 pairs,divided into 3 groups were killed alternately on the 2nd,8th and 16th week. The healing of their abdominal wall defects were then analyzed by comparing the rate of wound infection, the complete healing time,the thickness of the healing tissue and pathological changes under the microscopy. Results There was no mortality in the rats which had their defect repaired by NonnalGEN. In polyester surgical patch group,two rats died of infection, and 10 rats were healed up at the end. Conclusion NonnalGEN has a higher bio-compatibility to repair abdominal wall defects compared to polyester surgical patch.