| 慢性HBV感染者的T细胞亚群与拉米夫定临床疗效的关系 |
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| 引用本文： | 阎双缓,王素平,张新元,孔丽,曹治宸,马艳品,陈翠英. 慢性HBV感染者的T细胞亚群与拉米夫定临床疗效的关系[J]. 河北医药, 2009, 31(12): 1433-1434 |
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| 作者姓名： | 阎双缓 王素平 张新元 孔丽 曹治宸 马艳品 陈翠英 |
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| 作者单位： | 河北省石家庄市第五医院感染五科,050021;河北医科大学第三医院 |
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| 基金项目： | 河北省科技厅资助项目 |
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| 摘 要： | 目的 观察慢性乙型病毒性肝炎（CHB）患者应用拉米夫定（LAM）的临床疗效与免疫功能之间的关系。方法选择CHB患者20例,肝功能正常的乙型肝炎病毒（HBV）携带者15例,肝功能正常的HBsAg携带者15例及健康献血员20例（对照组）,用流式细胞术检测其外周血T细胞亚群;CHB患者给予LAM治疗,1年后再次检测T细胞亚群。结果CHB患者、HBV携带者CD4^＋、CD8^＋T细胞计数与对照组比较差异有统计学意义（P〈0．05）;HBsAg携带者T细胞亚群细胞计数与照组差异无统计学意义（P〉0．05）。结论不同类型的慢性HBV感染者免疫功能有不同特点;LAM治疗CHB的临床疗效与免疫功能有密切关系。
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| 关 键 词： | 乙型肝炎病毒 T细胞亚群 免疫应答 拉米夫定 |
The correlation between T-lymphocyte subsets and clinical efficacy of lamivudine in patients with chronic hepatitis B |
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| YAN Shuanghuan,WANG Suping,ZHANG Xinyuan,et al.. The correlation between T-lymphocyte subsets and clinical efficacy of lamivudine in patients with chronic hepatitis B[J]. Hebei Medical Journal, 2009, 31(12): 1433-1434 |
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| Authors: | YAN Shuanghuan WANG Suping ZHANG Xinyuan et al. |
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| Affiliation: | YAN Shuanghuan,WANG Suping,ZHANG Xinyuan,et al.The Fifth Hospital of Shijiazhuang,Shijiazhuang 050021,China |
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| Abstract: | Objective To investigate the changes of T-lymphocyte subsets in different types of HBV infecters,and to observe the relationship between therapeutic effects of LAM and immune function in patients with chronic hepatitis B(CHB).Methods 20 patients with CHB were enrolled in the study.Simultaneously selected 15 HBV carriers and 15 HBsAg carriers whose liver function was normal.20 healthy volunteers were served as normal controls.Flow cytometry was used to detect T lymphocyte subsets.All the patients were treate... |
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| Keywords: | HBV T-lymphocyte subsets immune response LAM |
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