头孢呋辛酯固态分散体形成和增加溶出的机制

 目的探讨头孢呋辛酯-聚维酮固态分散体形成和改善溶出的机制。方法采用溶剂法制备头孢呋辛酯-聚维酮固态分 散体，利用差熟分析，X射线衍射，扫描电镜等方法研究固态分散体中头孢呋辛酯的晶体性质，研究不同比例物理混合物和固态分散体的累积溶出速率。结果药物的晶型消失，累积溶出速率明显增加。结论通过固态分散法，药物以无定形分散于栽体中，显著改善其溶出。

The formation and solubilization of cefuroxime axetil solid dispersion

OBJECTIVE To study the formation and solubilization mechanism of cefuroxime axetil solid dispersion.METHODS The solid dispersion of cefuroxime axetil and PVP was made by solvent evaporation method.By using DSC,X ray diffraction and SEM,the polymorphism of cefuroxime axetil in solid dispersion was investigated. The cumulative dissolution rates of a series of the solid dispersions and physical mixtures were determed.RESULTS The crystal form of drug disappeared in the dispersion and the cumulative dissolution increased evidently.CONCLUSIONS By using solid dispersion methods, the drug was dispersed in PVP in the amorphous form and its solubility was increased.