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糖尿病终末期肾病血液透析患者C-反应蛋白水平
引用本文:曹礼应,余月明,郭虹,段建,王柏青. 糖尿病终末期肾病血液透析患者C-反应蛋白水平[J]. 昆明医学院学报, 2005, 26(4): 78-81
作者姓名:曹礼应  余月明  郭虹  段建  王柏青
作者单位:成都军区昆明总医院肾内科,昆明,650032
摘    要:目的:探讨糖尿病终末期肾病(end stage renal disease-diabetes mellitus,ESRD-DM)维持性血液透析(hemodialysis,HD)患者C-反应蛋白(C-reactive protein,CRP)变化.方法:29例ESRD-DM及同期20例ESRD的HD患者采血测定红细胞数(RBC)、血红蛋白(Hb)、红细胞比积(Hct)、血浆总蛋白(TP)、白蛋白(Alb)、血肌酐(Scr)、尿素氮(BUN)、胆固醇(TCH)、三酰甘油(TG)和纤维蛋白原(Fib)、CRP,分析高血压和冠心病的患病率.结果:ESRD-DM的HD患者RBC,Hb、Hct、TP、Alb、Ser、BUN均显著低于ESRD的HD患者,而冠心病的患病率、血CRP、Fm水平显著高于ESRD的HD患者;ESRD-DM的HD患者CRP与Hb、Hc、Alb呈显著负相关.结论:ESRD-DM的HD患者贫血及低蛋白血症较严重.血CRP显著升高,冠心病的患病率较高,贫血、低蛋白血症、冠心病的发病可能与炎症反应有一定的关系.

关 键 词:终末期肾病 糖尿病 血液透析 C-反应蛋白
文章编号:1003-4706(2005)04-0078-04
收稿时间:2005-07-10
修稿时间:2005-07-10

Serum C-reactive Protein in Diabetes Patients with End- stage Renal Disease Undergoing Hemodialysis
CAO Li-ying,YU Yue-ming,GUO Hong,DUAN Jian,WANG Bai-qing. Serum C-reactive Protein in Diabetes Patients with End- stage Renal Disease Undergoing Hemodialysis[J]. Journal of Kunming Medical College, 2005, 26(4): 78-81
Authors:CAO Li-ying  YU Yue-ming  GUO Hong  DUAN Jian  WANG Bai-qing
Affiliation:Dept. of Nephrology, Kunming General Hospital of Chengdu Military Region, Kunming 650032, Chiha
Abstract:Objective: To investigate serum C-reactive protein(CRP) levels in diabetes mellitus(DM) patients with end stage renal disease(ESRD) undergoing hemodialysis(HD).Methods: 29 ESRD-DM and 20 ESRD maintenance HD patients were studied and their bloods were sampled at the day on HD for the determination of red blood cell(RBC),hemoglobin(Hb),hematocrit(Hct),total protein(TP),serum albumin(Alb),serum creatinine(Scr),blood urea nitrogen(BUN),fibrinogen(Fib) and CRP;The rate of coronary artery disease(CAD) and hypertension was analyzed.Results: The levels of RBC,Hgb,Hct,TP,Alb,Scr,BUN in ESRD-DM maintenance HD patients were lower than ESRD maintenance HD patients;but the rate of CAD, serum CRP,Fib were higher than patients with ESRD maintenance HD;The serum-CRP was negatively correlated with Hb,Hct and Alb in patients with ESRD-DM maintenance HD.Conclusion: The anemia and hypoproteinemia in ESRD-DM maintenance HD patients were more severe than ESRD maintenance HD patients,serum CRP and the rate of CAD were significantly higher than patients with ESRD maintenance HD.Anemia,hypoproteinemia and the rate of CAD might be related to micro-inflammation state in ESRD-DM maintenance HD patients.
Keywords:End stage renal disease   Diabetes mellitus   Hemodialysis   C- reactive protein
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