| 蚕梅方提取物对AOM/DSS诱发腺瘤性息肉小鼠的防治作用 |
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| 引用本文： | 张华月,马新文,鄂裘恺,丁亚琴,张兆洲,蔡刚,温昊天,付晓伶. 蚕梅方提取物对AOM/DSS诱发腺瘤性息肉小鼠的防治作用[J]. 上海中医药大学学报, 2018, 32(1): 55-59 |
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| 作者姓名： | 张华月 马新文 鄂裘恺 丁亚琴 张兆洲 蔡刚 温昊天 付晓伶 |
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| 作者单位： | 上海中医药大学附属曙光医院肿瘤科;南京医科大学生殖医学国家重点实验室;上海中医药大学附属市中西医结合医院内分泌科; |
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| 基金项目： | 国家自然科学基金青年基金资助项目(81403360) |
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| 摘 要： | ![]()
目的:探讨蚕梅方(由僵蚕、乌梅组成)提取物对AOM/DSS诱发小鼠腺瘤性肠息肉的防治作用。方法:以C57BL/6小鼠为研究对象,随机分为正常组、模型组、阳性对照组(阿司匹林组)、蚕梅低剂量组(0.65 g/ml)、蚕梅高剂量组(2.6 g/ml)。除正常组外,其余各种采用AOM/DSS诱发小鼠结直肠腺瘤性息肉模型,并于造模过程中各药物组予相应的药物灌胃干预。实验结束,比较各组结直肠腺瘤个数及抑瘤率,并以免疫组化法检测结肠黏膜细胞周期蛋白D1(Cyclin D1)表达水平;应用ELISA检测小鼠血浆白介素-6(IL-6)表达水平。结果:经93 d灌胃给药,阳性对照组、蚕梅高剂量组、蚕梅低剂量组腺瘤抑制率分别为14.49%、70.45%、8.78%,与阳性对照组比较蚕梅高剂量组有显著抑制腺瘤作用(P0.05),且蚕梅高剂量组能显著降低Cyclin D1阳性发生率(P0.05);与正常组比较,模型组和阳性对照组IL-6高表达,蚕梅方低剂量组和高剂量组可显著下调IL-6表达(P0.05)。结论:蚕梅方提取物能显著降低AOM/DSS小鼠腺瘤性息肉的发生率,且有明显的量效关系;其作用机制可能与抑制Cyclin D1、显著下调IL-6表达有关。
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| 关 键 词： | 蚕梅方 醇提物 腺瘤性息肉 IL-6 Cyclin D1 小鼠 |
Preventive and therapeutic effects of Canmei Prescription Extracts on AOM/DSS induced adenomatous polyp in mice |
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| ZHANG Huayue,MA Xinwen,E Qiukai,DING Yaqin,ZHANG Zhaozhou,CAI Gang,WEN Haotian and FU Xiaoling. Preventive and therapeutic effects of Canmei Prescription Extracts on AOM/DSS induced adenomatous polyp in mice[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2018, 32(1): 55-59 |
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| Authors: | ZHANG Huayue MA Xinwen E Qiukai DING Yaqin ZHANG Zhaozhou CAI Gang WEN Haotian FU Xiaoling |
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| Affiliation: | Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China,Department of Endocrinology,Municipal Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | ![]()
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