二大归芷膏对掌跖角化型皮肤病血清中IL-18表达的影响

目的:了解二大归芷膏对掌跖角化型皮肤病血清中IL-18表达的影响。方法:用酶联免疫吸附法(ELISA)测定180例(治疗组和对照组)掌跖角化型皮肤病患者治疗前后血清IL-18的浓度,并和150例健康对照者比较。结果:治疗前治疗组与正常组比较P<0.01;治疗组治疗前后比较,P<0.01;治疗后治疗组与对照组比较P<0.05。结论:二大归芷膏能通过降低掌跖角化型皮肤病患者血清中IL-18表达的作用而达到治疗的目的,且效果优于对照组。为进一步研究掌跖角化型皮肤病的病因病机提供了新思路,为治疗掌跖角化型皮肤病提供了新方法。

Impact of Erda Guizhi Extract on IL-18 Expression in Plasm of Keratodermia Patients

Objectives:to understand impact of Erda Guizhi Extract on IL-18 expression in plasm of keratodermia patients.Methods:Concentration of IL-18 of the treatment group(90cases)and the control group(90cases)were detected before and after treatment by Enzyme Linked Immuno-sorbent Assay(ELISA)and compared with healthy control(90cases).Results:Before treatment,the treatment group was significantly different with the healthy control(P<0.01);Improvement was significant for the treatment group after treatment(P<0.01);so was differences between the treatment and control group(P<0.01).Conclusions:Erda Guizhi Extract is more favorable than the control group in treating keratodermia by cutting down IL-18 expression in plasm of keratodermia patients.The experiment provides new thoughts of thinking for further study on pathogenesis and cause of keratodermia,suggesting new methods for treatment.