抗-H抗体引起血型鉴定困难3例报告

抗-H抗体属于IgM型冷抗体，临床鉴定血型时，常可引起正反定型不符，造成定型困难。在反定型鉴定血型时发现的抗-H抗体中，3例患者经血型血清学检测，抗体在37℃、室温、4℃均有活性，分析抗体性质为IgM，提示紧急时刻给AB型患者输血，不能盲目输注O型红细胞，最好输注同型血。如果没有同型时，需输O型红细胞，先用盐水离心法配血，主侧配血相合时方可发出，再用不完全法检测。防止患者有抗-H抗体存在，引起输血不良反应。

Report on Difficulty in Blood Group Identification due to Anti-H Antibody in Three Cases

Anti-H antibody belongs to IgM type cold antibody, which often induces the unconformity of positive and reverse typing and leads to the difficulty in clinical blood typing. Anti-H antibody was found during identification of the counter blood group in 3 cases. The antibody was found to be active at 37 degrees C, room temperature and 4 degrees C when determined by blood group serology, and was finally analyzed to be IgM. It is suggested that not to give erythrocytes of O group unreasoningly to blood recipient of AB group during emergent moment, but instead, to give same type of blood. If there was no same type of blood during urgent events, O type erythrocytes could be employed after being matched by saline centrifuging with host side coincidence and screened by incomplete method. In this case, anti-H antibody leading to adverse-reaction in blood transfusion should be prevented.