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| 多西环素对心血管重构的影响及其临床意义 | |
| 引用本文： | 沈丽娟 何国平. 多西环素对心血管重构的影响及其临床意义[J]. 国外医学(药学分册), 2007, 34(2): 103-105 |
| 作者姓名： | 沈丽娟 何国平 |
| 作者单位： | 江苏大学附属武进医院,江苏常州213002 |
| 摘 要： | 基质金属蛋白酶是心血管重构的重要推动力。研究已经证实，半合成四环素类抗生素——多西环素不但具有广谱的抗菌作用，而且还能抑制基质金属蛋白酶的表达和活性，从而有望为心血管重构的防治开辟新途径。 |
| 关 键 词： | 心血管重构 基质金属蛋白酶 多西环素 |
| 文章编号： | 1001-0971（2007）02-0103-03 |
| 修稿时间： | 2006-08-18 |
Effect of doxycycline on cardiovascular remodeling and its clinical significance |
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| SHEN Li-juan, HE Guo-ping. Effect of doxycycline on cardiovascular remodeling and its clinical significance[J]. Foreign Medical Sciences(Section of Pharmarcy), 2007, 34(2): 103-105 | |
| Authors: | SHEN Li-juan HE Guo-ping |
| Affiliation: | Affiliated Wujin Hospital, Jiangsu University, Changzhou 213002, China |
| Abstract: | Matrix metalloproteinase(MMP) is the important impetus of cardiovascular remodeling. Studies have made sure that semisynthetic tetracyclinesdoxycycline not only has broad antibacterial effect, but also inhibits MMP expression and activity. Thereby it is hopeful to inaugurate a new way for prevention and treatment of the cardiovascular remodeling. |
| Keywords: | cardiovascular remodeling matrix metalloproteinase doxycycline |
| 本文献已被 CNKI 维普 等数据库收录！ | |