VEGF、p21ras在鼻咽癌组织中的表达及其临床意义的研究

目的 :研究 VEGF及 p2 1ras蛋白表达与鼻咽癌临床生物学特性及预后的关系 ,更好地评估预后 ,指导临床治疗。方法 :用免疫组化法测定 81例鼻咽低分化鳞癌 VEGF及 p2 1ras蛋白表达 ,对阳性和阴性病例进行统计分析。结果 :VEGF在不同分期、颈淋巴结转移、放疗后远处转移病例中的表达有显著性差异 (P<0 .0 5 ) ,p2 1ras蛋白高表达 ,但与不同分期、局部复发、颈淋巴结转移、远处转移无关。单因素分析显示影响鼻咽癌生存的预后因素有临床分期 (P<0 .0 5 )和癌组织中 VEGF表达水平 (P<0 .0 5 )。 Cox逐步回归模型分析显示临床分期是鼻咽癌的独立预后因素。结论 :鼻咽癌组织中 VEGF表达与临床 N分期、颈淋巴结转移、远处转移有显著相关 ;单因素分析 VEGF表达与鼻咽癌的预后呈正相关 ,可考虑作为预测鼻咽癌患者放射治疗后远处转移和预后的因素之一。 p2 1ras蛋白高表达 ,但与颈淋巴结转移、远处转移、局部复发无关 ,可作为联合检测的指标之一用于肿瘤的早期诊断。 VEGF表达与 p2 1ras蛋白表达无相关性。

A STUDY ON TISSUE VEGF,p21ras PROTEIN DETECTION AND ITS CLINICAL SIGNIFICANCE IN NASOPHARYNGEAL CARCINOMA

Objective:To study the VEGF and p21 ras protein expression and its clinical significance in nasopharyngeal carcinoma.Methods:The expression of VEGF and p21 ras in nasopharyngeal carcinoma tissue was determined by immunochemical technique.Results:There were obvious difference in tissue VEGF protein expression with different clinical N-Staging, cervical lymph nodes metastasis and distant metastasis. There were no difference in tissue p21 ras protein expression with different clinical N-Staging, cervical lymph nodes metastasis and distant metastasis.Conclusion:1.The positive expression of VEGF can be one of the prognostic factors in NPC. 2. p21 ras protein expression has no relationship with prognosis,but can be used as one of the early diagnosis method for its higher expression . 3.There is no correlation between VEGF and p21ras.